Une femme célibataire de la Nouvelle-Angleterre répond à une annonce d'un veuf du Midwest dans laquelle il demande une épouse pour l'aider à élever ses deux enfants.
The Prairie is set at the time of the Louisiana Purchase. Hoping to find their destiny in the new territory, the Bush Family heads southward in a covered wagon. Sharing the family's numerous dangers and hardships are Ellen Wade (Lenore Aubert), sole survivor of an Indian attack, and army mapmaker Paul Hover (Alan Baxter). Cousins Abiram (Russ Vincent) and Asa (Jack Mitchum) duke it out over Ellen's affections
Jacob's farm is in trouble from a severe drought. Jacob and Sarah begin to wonder if Sarah can stay, and what will happen to Jacob if she and the children have to leave the farm.