Vijay enjoys the good life: happily married, wealthy and a beautiful daughter. However, one summer, when his daughter brings a friend back to stay, their familial bliss is shattered.
Sanjay souffre d'amnésie antérograde : il ne se rappelle que des quinze dernières minutes qui se sont écoulées. Mais Sanjay se souvient d'une chose, un nom : Ghajini. Et Sanjay est près à tout pour se venger de l'homme qui lui a fait tout perdre...
Believing himself to be a jinx and bringing bad luck upon himself and others, a man attempts to find true love, but ends up in very complicated relationships.